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Category: Sarms


MK677 – Ibutamoren SARMs Profile

Drug Class: Selective Androgen Receptor Modulators (SARMs)

Half-Life: Approximately 24 hours

Chemical Formula: C27H36N4O5S

MK-677, also known as Ibutamoren, is a non-peptide, influential, long-lasting, and selective agonist of ghrelin receptors in the world of bodybuilders and athletes. MK-677 raises the growth hormone level in the blood by intimidating the action of ghrelin hormone (a hormone produced by our stomach) and acts on the ghrelin receptor (GHSR) in the brain.

MK-677 is an orally active non-peptide spiropiperidine elevating the level of insulin-like growth factor (IGF-1). It has a long half-life of 24 hours which contributes to its potential of mimicking the action of ghrelin. Usually, athletes and bodybuilders use MK-677 because of its ability to build fat-free muscles and suppress muscle wasting.

What Are SARMs?

SARMs are androgen receptor ligands. They are used to develop anabolic activity and have the same effect as androgenic drugs but are highly specific in their actions, allowing their more usage than other anabolic drugs.

Selective androgen receptor modulators are protagonists at androgen receptors and initiate them to stimulate anabolic activity and muscle growth. That’s why SARMs play a vital role in building muscle mass and decreasing body fat. SARMs are also beneficial for many health complications such as anaemia, wound healing, osteoporosis, breast cancer, Alzheimer’s disease, male contraception, and male hypogonadism.

How Does MK-677 Work?

MK-677 aka Ibutamoren intimates the action of ghrelin, a hormone secreted by the stomach, and acts on the ghrelin receptors in the hypothalamus. The action of Ibutamoren on ghrelin receptors results in the secretion of growth hormone-releasing hormone (GHRH) from the hypothalamus, enhancing the activity of GHRH in the anterior pituitary. This leads to increased secretion of growth hormone from the anterior pituitary making the mk677 the most potent growth hormone secretagogue. Also, mk677 seems to increase the blood levels of IGF-1 (Insulin-like growth factor 1).

An inhibitor of growth hormone, Somatostatin is antagonised by MK-677 by inhibiting the somatostatin receptor signalling.

Benefits Of Using MK-677 or Ibutamoren:

The benefits of using MK-677 or Ibutamoren are because of its selectivity and specificity for the androgen receptor in muscles. Here are some remarkable benefits that one can get by using Ibutamoren MK-677.

Growth And Development of Muscles:

MK-677 is widely used as an anabolic substance (a process of constructive metabolism). Studies suggested that mk677 is beneficial in patients with muscle wasting and gait abnormalities. The growth hormone and insulin-like growth factor 1 (IGF-1) releasing action of MK-677 make it effective for building a lean body.

Increase Endurance:

A scientific study revealed that ibutamoren (mk677) also increases the body’s endurance, strength, and stamina. It might be due to the increase in the expression of an organelle called mitochondria that produces most of the energy in the body.

Increase Bone Density:

Osteoporosis (bone weakness), pain & stiffness in bones, and too much weight acting on the bones in obese people are the most common issues. To help with these issues, mk677 is an astonishing drug to improve bone mineral density and prevent osteoporosis. Experimental data shows that it increases bone mineral adsorption via growth hormone.

Reduce Body Fat:  

Ibutamoren is beneficial for athletes and bodybuilders as they are very conscious of their body weight. Mk-677 stimulates the breakdown of fat (lipolysis), leading to bodyweight reduction.

Improve Sleep Quality:

Ibutamoren MK-677 improves sleep quality and prolongs the rapid eye movement (REM) phase of sleep as it enhances the production of growth hormones.

Promote Wound Healing:

Some people believe that mk677 promotes wound healing and tissue regeneration due to the increased production of growth hormones.

MK-677 Dose:

One of the great features of MK-677 is that it is very well tolerated, even if used for an extended period and in high doses. The typical dose is between 10 to 50 mg per day. At 25 mg, some side effects were reported, including increased water retention, anxiety, and fatigue, but they are not fatal. However, one should start with a lower dosage and increase it gradually if needed.

What Are the Side Effects of Ibutamoren or MK-677?

The reported side effects of MK-677 are commonly due to the high level of growth hormone in the body by excessive, irregular, or long-term use of ibutamoren. Following are some significant side effects of using MK-677:

  • Lethargy: With the use of MK-677, some people experience lethargy due to a reduction in testosterone levels in the body. This is because SARMs suppress the production of testosterone in the body.
  • Headache: Using ibutamoren for the long term can also cause fatigue and headache.
  • Joint Pain: Long-term usage of mk677 can cause stiffness, severe pain, or rigidity in the joint. Therefore, you should be careful while using SARMs.
  • Acne:Excessive use of MK-677 raises the androgen level in the body. Due to this, a user may report acne after using MK-677.

Where Can You Buy an Ibutamoren MK-677 Online?

UK SARMs are the most demanding supplements in the market. But where to buy a 100% genuine mk677 UK SARM supplement? It is important to opt for genuine, high-quality mk677 UK SARMs, as some products lack the key supplements. Prohormones or steroids are used in place of SARMs to enhance their action. Always consult your healthcare professional before using any dietary supplementation.

To conclude, if you and you are planning to buy SARMs UK especially Ibutamoren MK677 then you are in the right spot by visiting our UK SARMs store. Please do consider everything above before the purchase and if you need any further assistance don’t hesitate and drop us a line and we will be happy to assist to best possible way.


  1. Omega, B. (2022). Ibutamoren (MK-677). Peptides by BeringOmega. Retrieved January 28, 2022, from https://beringomega.org/product/ibutamoren-mk677/
  2. MG, M. (2022). MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. The Journal of clinical endocrinology and metabolism. Retrieved January 28, 2022, from https://pubmed.ncbi.nlm.nih.gov/9467534/
  3. Foundation, W. (2021, November 17). Ibutamoren. Wikipedia. Retrieved January 28, 2022, from https://en.m.wikipedia.org/wiki/Ibutamoren
  4. Trials , C. (2007). Effects of an oral GH secretagogue (MK-677) on body composition and functional ability of older adults – full text view. Effects of an Oral GH Secretagogue (MK-677) on Body Composition and Functional Ability of Older Adults – Full Text View – ClinicalTrials.gov. Retrieved January 28, 2022, from https://clinicaltrials.gov/ct2/show/NCT00474279
  5. Murphy, M. G., Plunkett, L. M., Gertz, B. J., He, W., Wittreich, J., Polvino, W. M., & Clemmons, D. R. (1998, February 1). MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism1. OUP Academic. Retrieved January 28, 2022, from https://academic.oup.com/jcem/article/83/2/320/2865101
  6. You, T. (2021). MK-677: Explanation, benefits, side effects. MK-677: Explanation, Benefits, Side Effects. Retrieved January 28, 2022, from https://www.transformyou.com/mk-677
  • 100% legit . Strong
    Posted on 12.09.2023
    Thomas Magnier